I’ve done DXM solo several times at 2nd plateau without issue. I’d read about the DXM+cannabis combo and decided to try it cautiously. I want to document this honestly.
My Setup
200mg DXM HBr (I’m 82kg so ~2.4mg/kg). Cannabis: I waited until the DXM had fully come up (T+1:30) and took one small hit from a vaporizer. I deliberately kept the cannabis amount tiny.
What Happened
The interaction was dramatically more potent than I expected from such a small amount of cannabis. Within 10-15 minutes of the cannabis, the dissociation jumped from “interesting and manageable” to “very intense.” A wave of anxiety came with it — my thoughts accelerated and became difficult to follow, and the dissociation felt threatening rather than euphoric.
Managing It
I reminded myself repeatedly that this was temporary and that I had not taken anything dangerous. Focused on breathing. Stayed lying down. The anxiety peaked at about T+2:15 and gradually became more manageable over the next hour.
The end of the experience (T+2:30 onward) was actually very pleasant — a warm, floaty afterglow with much of the anxious edge gone. But the 45-minute period of intense anxiety was uncomfortable.
What I’d Do Differently
If I try this combination again: even smaller cannabis amount, or wait until the DXM is more peaked and declining. The synergy is real and it’s more than additive. Treat the combined dose like it’s a full plateau higher than the DXM alone.
I would not recommend this combo for anyone with anxiety tendencies or low experience.